| 产品名称 | Human IL-6 Protein |
|---|---|
| 中文名称 | 重组人白介素-6 |
| 种属 | Human |
| 表达宿主 | E. coli |
| 纯度 | > 98 % as determined by SDS-PAGE |
| 内毒素 | <0.1 EU per μg of the protein as determined by the LAL method. |
| 生物活性 | Measured in a cell proliferation assay using TF-1. The ED50 for this effect is typically 2.25 ng/mL. The specific activity of recombinant Human IL6 is approximately >4.44 x 105 IU/mg. |
| 基因编号 | 3569 |
| 蛋白链接 | http://www.uniprot.org/uniprot/P05231/entry |
| 别名 | BSF2; HGF; HSF; IL-6; Interleukin-6; Interleukin-6; IL6 |
| 蛋白序列 | MVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM |
| 蛋白标签 | Tag free |
| 预测分子量 | The recombinant human IL-6 consists of 187 amino acids and migrates with an apparent molecular mass of 20.6 kDa as estimated in SDS-PAGE under reducing conditions |
| 产品形式 | Lyophilized from sterile 150mM NaCl 20mM Tris , pH 8.0 |
| 使用方式 | Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human IL-6 protein in sterile ddH2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions |
| 运输方式 | The product is shipped at ambient temperature. |
| 储存条件 | Store at-20°C |
| 产品背景 | Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity. |
*本产品仅供科研试验用，不可直接用于人体。
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