| 产品名称 | Human IL-11 Protein |
|---|---|
| 中文名称 | 重组人白介素11 |
| 种属 | Human |
| 表达宿主 | E. coli |
| 纯度 | > 95 % as determined by SDS-PAGE |
| 内毒素 | <1.0 EU per μg of the protein as determined by the LAL method. |
| 生物活性 | Measured by its ability to induce proliferation in TF-1 cells. The ED50 for this effect is 1.982 ng/mL.The specific activity of recombinant Human IL-11 is approximately >0.50 x 106 IU/mg. |
| 基因编号 | 3589 |
| 蛋白链接 | https://www.uniprot.org/uniprotkb/P20809/entry |
| 别名 | IL-3; Hematopoietic growth factor; Mast cell growth factor (MCGF); Multipotential colony-stimulating factor; P-cell-stimulating factor |
| 蛋白序列 | PGPPPGPPRVSPDPRAELDSTVLLTRSLLADTRQLAAQLRDKFPADGDHNLDSLPTLAMSAGALGALQLPGVLTRLRADLLSYLRHVQWLRRAGGSSLKTLEPELGTLQARLDRLLRRLQLLMSRLALPQPPPDPPAPPLAPPSSAWGGIRAAHAILGGLHLTLDWAVRGLLLLKTRL |
| 蛋白标签 | Tag free |
| 预测分子量 | The recombinant Human IL-11 consists of 178 amino acids and predicts a molecular mass of 19.14KDa |
| 产品形式 | Lyophilized from sterile 20 mM Tris with 150 mM NaCl, pH 7.4. |
| 使用方式 | Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized recombinant Human IL-11 Protein using the buffer we provided not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| 运输方式 | The product is shipped at ambient temperature. |
| 储存条件 | Store at -20℃ |
| 产品背景 | IL11 is a multifunctional cytokine first isolated in 199 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 is also known under the names adipogenesis inhibitory factor (AGIF) and oprelvekin. IL11 can improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute-phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation, and could be used as a therapeutic for osteoporosis. IL11 stimulates the growth of certain lymphocytes and, in the murine model, stimulates an increase in the cortical thickness and strength of long bones. As a signaling molecule, IL11 has a variety of functions associated with its receptor interleukin 11 receptor alpha; such functions include placentation and to some extent of decidualization. |
*本产品仅供科研试验用，不可直接用于人体。
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