| 产品名称 | Human IL 17A protein |
|---|---|
| 中文名称 | 重组人白介素17A |
| 种属 | Human |
| 表达宿主 | E. coli |
| 纯度 | >95 % as determined by SDS-PAGE |
| 内毒素 | < 0.1 EU per μg of the protein as determined by the LAL method. |
| 生物活性 | Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells.The ED50 for this effect is 7.582 ng/mL, corresponding to a specific activity is 1.32×105 U/mg. |
| 基因编号 | 3605 |
| 蛋白链接 | https://www.uniprot.org/uniprotkb/Q16552/entry#sequences |
| 别名 | IL-17; IL-17A；Cytotoxic T-lymphocyte-associated antigen 8 (CTLA-8) |
| 蛋白序列 | GITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA |
| 蛋白标签 | Tag Free |
| 预测分子量 | The recombinant Human IL-17Aconsists of 136 amino acids and predicts a molecular mass of 15.7 kDa. |
| 产品形式 | Lyophilized from 20 mM Tris-HCl, 50 mM NaCl, pH8.0. |
| 使用方式 | Lyophilized protein product should be stored desiccated below-20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days . For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| 运输方式 | The product is shipped at ambient temperature. |
| 储存条件 | Store at -20℃ |
| 产品背景 | Interleukin-17A (IL-17A), also known as CTLA-8, belongs to the IL-17 cytokine family. IL-17A is expressed in memoryTh17 cells and is a product of memory CD4+Tcells. In addition to Th17 cells, IL-17Acan also be produced by various immune cells, including CD8+T cells γδ T cells, natural killer T (NKT) cells, monocytes, and neutrophils. IL-17A plays a crucial role in the host's defense mechanisms against many bacterial and fungal pathogens, as well as in allergic and autoimmune responses. IL-17A plays a role in viral infection by promoting neutrophil inflammation. IL-17A is a homodimeric cytokine with similar biological activity to IL-17F. IL-17A and IL-17RA have high affinity binding, and IL-17RA is essential for the biological activity of IL-17A. IL-17A cannot bind to T cells, B cells, and myeloid cells lacking IL-17RA. IL-17A is associated with various autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, asthma, and psoriasis. IL-17A also plays a pathogenic role in cancer. During tumor development, IL-17A recruits bone marrow-derived suppressor cells (MDSCs) to suppress anti-tumor immunity. IL-17A also promotes tumor growth in vivo by inducing IL-6. |
*本产品仅供科研试验用，不可直接用于人体。
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