| 产品名称 | Human NT-3 protein |
|---|---|
| 中文名称 | 重组人神经营养因子-3 |
| 种属 | Human |
| 表达宿主 | E. coli |
| 纯度 | >95 % as determined by SDS-PAGE |
| 内毒素 | < 0.1 EU per μg of the protein as determined by the LAL method. |
| 生物活性 | Measured by its binding ability in a functional ELISA. Immobilized human NT3 at 1 μg/mL(100 μL/well) can bind human TrkB-Fch. The EC50 of human TrkB-Fch is 26.38 ug/mL. |
| 基因编号 | 4908 |
| 蛋白链接 | http://www.uniprot.org/uniprot/P20783 |
| 别名 | HDNF ; NGF-2 ; NGF2 ; NT-3; NT3 |
| 蛋白序列 | YAEHKSHRGEYSVCDSESLWVTDKSSAIDIRGHQVTVLGEIKTGNSPVKQYFYETRCKEARPVKNGCRGIDDKHWNSQCKTSQTYVRALTSENNKLVGWRWIRIDTSCVCALSRKIGRT |
| 蛋白标签 | N-His |
| 预测分子量 | The recombinant Human NT-3 consists of 119 amino acids with 6 ×His tag at N- terminus and has a predicted molecular mass of 16 kDa. |
| 产品形式 | Liquid in sterile 20 mM Tris ,10% Glycerol, pH 8.0. |
| 使用方式 | Human NT-3 protein product should be stored desiccated below -20°C. The protein should be stored at 4°C between 2-7 days. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA ). Please prevent freeze-thaw cycles. |
| 运输方式 | The product is shipped at ambient temperature. |
| 储存条件 | Store at -20℃ |
| 产品背景 | Human Neurotrophin-3 (NT-3) is a member of the neurotrophin family, that controls the survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. NT-3 is a key mediator of neuronal development during the early neurogenic period. NT-3 is a novel target gene of POU3F2 and that the POU3F2/NT-3 pathway plays a role in the process of neuronal differentiation. NT-3 is capable of activating TrkB to induce anoikis resistance, and show that NT-3 is also a direct target of miR-200c. NT-3 is broadly expressed in the ovary, spleen, and other tissues. Diseases associated with NT-3 include Hypochondriasis and Demyelinating Disease. |
*本产品仅供科研试验用，不可直接用于人体。
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