Human/Mouse/Rat BDNF protein (Animal-Free)
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| 产品名称 | Human/Mouse/Rat BDNF protein (Animal-Free) |
|---|---|
| 中文名称 | 重组人/小鼠/大鼠脑源性神经营养因子（无动物源） |
| 种属 | Human |
| 表达宿主 | E. coli |
| 纯度 | >98 % as determined by SDS-PAGE |
| 内毒素 | < 0.1 EU per μg of the protein as determined by the LAL method. |
| 生物活性 | Measured by its binding ability in a functional ELISA. Immobilized Human/Mouse/Rat BDNF protein at 1 μg/mL(100 μL/well) can bind human TrkB-Fch. The EC50 of human TrkB-Fch is 46.96 ug/mL. |
| 基因编号 | 627 |
| 蛋白链接 | https://www.uniprot.org/uniprotkb/P23560/entry |
| 别名 | ANON2, BULN2 |
| 蛋白序列 | HSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR |
| 蛋白标签 | Tag Free |
| 预测分子量 | The recombinant Human/Mouse/Rat BDNF protein consists of 119 amino acids and predicts a molecular mass of 14.45 kDa |
| 产品形式 | The protein was lyophilized from 20 mM sodium citrate, 0.2 M NaCl, pH 3.5. |
| 使用方式 | Lyophilized protein product should be stored desiccated below-18°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days. For long term storage it is recommended to add a carrier protein (5% HSA , 10%FBS or 0.1%BSA). Please prevent freeze-thaw cycles. |
| 运输方式 | The product is shipped at ambient temperature. |
| 储存条件 | Store at -20℃ |
| 产品背景 | Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin that belongs to NGF-beta family. BDNF can bind to its high affinity receptor TrkB and activates signal transduction cascades (IRS1/2, PI3K, Akt). BDNF can also bind to the p75NTR, but the affinity for the p75NTR receptor is lower than for TrkB. BDNF is a neurotransmitter modulator, and is vital in maturation, survival and differentiation of neuronal populations during development. BDNF also participates in neuronal plasticity, which is essential for learning and memory. BDNF is widely expressed in the CNS. |
*本产品仅供科研试验用，不可直接用于人体。
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