Mouse IL-13 Protein, His tag (Animal-Free)
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| 产品名称 | Mouse IL-13 Protein, His tag (Animal-Free) |
|---|---|
| 中文名称 | 重组小鼠白介素-13，His-标签（无动物源） |
| 种属 | Mouse |
| 表达宿主 | E. coli |
| 纯度 | >95% as determined by SDS-PAGE |
| 内毒素 | < 1 EU per µg of the prot ein as determined by the LAL method. |
| 生物活性 | Measured in a cell proliferation assay using TF -1. The ED50 for this effect is typically 10.12 ng/mL. The specific activity of recombinant Mouse IL13 is approximately >9.88 x 104 IU/mg. |
| 基因编号 | 16163 |
| 蛋白链接 | https://www.uniprot.org/uniprotkb/P20109/entry |
| 别名 | 1L-13; T-cell activation protein P600 |
| 蛋白序列 | MALWVTAVLALACLGGLAAPGPVPRSVSLPLTLKELIEELSNITQDQTPLCNGSMVWSVDLAAGGFCVALDSLTNISNCNAIYRTQRILHGLCNRKAPTTVSSLPDTKIEVAHFITKLLSYTKQLFRHGPF |
| 蛋白标签 | C-His |
| 预测分子量 | The recombinant mouse IL13 protein consists of 118 amino acids and predicts a molecular mass of 12.7 kD.The apparent molecular mass of the mouse IL13 is approximately 15-30 kDa in SDS-PAGE under reducing conditions due to glycosylation. |
| 产品形式 | Lyophilized from sterile PBS, pH7.4. |
| 使用方式 | Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized mouse IL-13 protein in the buffer which we provide not less than 100 µg/mL, which can then be further diluted to other aqueous solutions. |
| 运输方式 | The product is shipped at ambient temperature. |
| 储存条件 | Store at -20℃ |
| 产品背景 | Interleukin (IL)-13, a cytokine produced by T helper 2 (Th2) cells, is a powerful inhibitor of macrophage functions, including surface expression of CD14 and production of IL-1 and tumor necrosis factor (TNF)-alpha. Interleukin (IL) -13 synergizes with IL2 in regulating interferon-gamma synthesis. It may be critical in regulating inflammatory and immune responses. Mouse IL13 shares 58% sequence identity with human protein and exhibits cross-species activity.IL-13 was first recognized for its effects on B cells and monocytes, where it upregulated class II expression, promoted IgE class switching and inhibited inflammatory cytokine production. It was also thought to be functionally redundant with IL-4. |
*本产品仅供科研试验用，不可直接用于人体。
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