| 产品名称 | Human FGF-19 protein |
|---|---|
| 中文名称 | 重组人成纤维细胞生长因子19 |
| 种属 | Human |
| 表达宿主 | E. coli |
| 纯度 | >95 % as determined by SDS-PAGE |
| 内毒素 | < 0.1 EU per μg of the protein as determined by the LAL method. |
| 生物活性 | Measured in a cell proliferation assay using NIH-3T3 mouse fibroblast cells. The EC50 for this effect is 24.96 ng/mL. |
| 基因编号 | 9965 |
| 蛋白链接 | https://www.uniprot.org/uniprotkb/O95750/entry |
| 别名 | FGF19 |
| 蛋白序列 | LAFSDAGPHVHYGWGDPIRLRHLYTSGPHGLSSCFLRIRADGVVDCARGQSAHSLLEIKAVALRTVAIKGVHSVRYLCMGADGKMQGLLQYSEEDCAFEEEIRPDGYNVYRSEKHRLPVSLSSAKQRQLYKNRGFLPLSHFLPMLPMVPEEPEDLRGHLESDMFSSPLETDSMDPFGLVTGLEAVRSPSFEK |
| 蛋白标签 | N-His |
| 预测分子量 | The recombinant Human FGF-19 consists of 195 amino acids and predicts a molecular mass of 21.8 kDa. |
| 产品形式 | Lyophilized from sterile 20mM Tris, 150mM NaCl, pH8.0. |
| 使用方式 | Lyophilized protein product should be stored desiccated below-20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days . For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| 运输方式 | The product is shipped at ambient temperature. |
| 储存条件 | Store at -20℃ |
| 产品背景 | Fibroblast growth factor 19 (FGF-19) is a secreted protein which belongs to the FGFs family. FGF-19 is expressed in fetal brain, cartilage, retina, and adult gall bladder. FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF receptors (FGFRs): FGFR-1,-2,-3, and-4, all with intrinsic tyrosine kinase activity. FGFRs can be important for regulation of glucose and lipid homeostasis. FGF19 has important roles as a hormone produced in the ileum in response to bile acid absorption. It has been shown to cause resistance to diet-induced obesity and insulin desensitization and to improve insulin, glucose, and lipid profiles in diabetic rodents. FGF-19 can be considered as a regulator of energy expenditure. |
*本产品仅供科研试验用，不可直接用于人体。
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