| 产品名称 | Human FGF16 Protein |
|---|---|
| 中文名称 | 重组人成纤维细胞生长因子16 |
| 种属 | Human |
| 表达宿主 | E. coli |
| 纯度 | > 98 % as determined by SDS-PAGE |
| 内毒素 | < 0.1 EU per μg of the protein by the LALmethod. |
| 生物活性 | Measured by its ability to induce proliferation in Balb/3T3 cells. The ED50 for this effect is 5.997 ng/mL. The Specific activity of recombinant Human FGF16 is approximately > 1.66x106 IU/mg. |
| 基因编号 | 8823 |
| 蛋白链接 | https://www.uniprot.org/uniprotkb/O43320/entry |
| 别名 | FGF16; Fibroblast Growth Factor 16; |
| 蛋白序列 | MAEVGGVFASLDWDLHGFSSSLGNVPLADSPGFLNERLGQIEGKLQRGSPTDFAHLKGILRRRQLYCRTGFHLEIFPNGTVHGTRHDHSRFGILEFISLAVGLISIRGVDSGLYLGMNERGELYGSKKLTRECVFREQFEENWYNTYASTLYKHSDSERQYYVALNKDGSPREGYRTKRHQKFTHFLPRPVDPSKLPSMSRDLFHYR |
| 蛋白标签 | Tag free |
| 预测分子量 | The recombinant Human FGF16 consists of 206 amino acids and predicts a molecular mass of 23.6 kDa. |
| 产品形式 | Lyophilized from 20 mM Tris-HCl, 500 mM NaCl, pH8.0. |
| 使用方式 | Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized recombinant protein to a concentration of 0.1-1 mg/mL using the buffer we provided, and keep at room temperature for at least 20 min to fully dissolve. Please avoid vortex vigorously. |
| 运输方式 | The product is shipped at ambient temperature. |
| 储存条件 | Store at -20℃ |
| 产品背景 | FGF16 is preferentially expressed in the heart after birth, suggesting its regulation is associated with tissue-specific chromatin remodeling and DNA-protein interactions. Mutation of the MEF2 site resulted in a blunting of FGF16 promoter activity in transfected neonatal rat cardiac myocytes, that chromatin remodeling and MEF2 binding in the FGF16 promoter contribute to expression in the postnatal heart. FGF16 involvement in the fine tuning of the human skeleton of the hand. Impaired FGF16 function may also be responsible for connective tissue symptoms in MF4 patients. |
*本产品仅供科研试验用，不可直接用于人体。
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