| 产品名称 | Human IGF1 Protein |
|---|---|
| 中文名称 | 重组人胰岛素样生长因子1 |
| 种属 | Human |
| 表达宿主 | E. coli |
| 纯度 | > 96 % as determined by SDS-PAGE |
| 内毒素 | < 1.0 EUper μg of the protein as determined by the LAL method. |
| 生物活性 | Measured in a cell proliferation assay using MCF-7 mouse embryonic fibroblasts. The ED50 for this effect is typically 0.2 ng/mL. The specific activity of recombinant Human IGF is approximately >5 x 106 IU/mg. |
| 基因编号 | 3479 |
| 蛋白链接 | https://www.uniprot.org/uniprotkb/P05019/entry |
| 别名 | Long R3 IGF-I; |
| 蛋白序列 | GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA |
| 蛋白标签 | Tag free |
| 预测分子量 | The Recombinant Human IGF1 Protein consists of 71 amino acids and predicts a molecular mass of 7.8 Kda. |
| 产品形式 | Lyophilized from sterile 20 mM Tris with 150 mM NaCl, pH 7.4. |
| 使用方式 | Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human IGF1 Protein using the buffer we provided not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| 运输方式 | The product is shipped at ambient temperature. |
| 储存条件 | Store at -20℃ |
| 产品背景 | IGF I, also known as Mechano Growth Factor, somatomedin-C, IGF-I, and IGF1, is a secreted protein that belongs to the insulin family. The insulin family, comprised of insulin, relaxin, insulin-like growth factors I and II ( IGF-I and IGF-II ), and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I expression is regulated by GH and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF1 / IGF-I may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. IGF1 / IGF-I stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also about enhancing glucose uptake. Defects in IGF1 / IGF-I are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness, and mental retardation. |
*本产品仅供科研试验用，不可直接用于人体。
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