| 产品名称 | Human PDGF-BB Protein |
|---|---|
| 中文名称 | 重组人血小板衍生生长因子BB |
| 种属 | Human |
| 表达宿主 | E. coli |
| 纯度 | > 98 % as determined by SDS-PAGE |
| 内毒素 | <1 EU per μg of the protein by the LAL method. |
| 生物活性 | Measured in a cell proliferation assay using BaIb/c 3T3. The ED50 for this effect is typically 2.588 ng/mL.The specific activity of recombinant Human PDGF-BB is approximately >3.86 x 105 IU/mg. |
| 基因编号 | 5155 |
| 蛋白链接 | https://www.uniprot.org/uniprotkb/P01127/entry |
| 别名 | PDGF subunit B; PDGF-2; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; Proto-oncogene c-Sis Becaplermin |
| 蛋白序列 | SLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVT |
| 蛋白标签 | Tag free |
| 预测分子量 | The recombinant Human PDGF-BB Protein consists of 109 amino acids and predicts a molecular mass of 12.3 kDa. |
| 产品形式 | Lyophilized from sterile PBS, pH7.4. |
| 使用方式 | Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized protein using the buffer we provided not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. |
| 运输方式 | The product is shipped at ambient temperature. |
| 储存条件 | Store at -20℃ |
| 产品背景 | Platelet derived growth factor (PDGF) is a potent mitogen and chemoattractant for mesenchymal and osteogenic cells and stimulates angiogenic molecules which play an essential role in bone regeneration. PDGF-BB is a member of PDGF family, which promotes cell proliferation, survival and migration, through binding to the tyrosine kinase PDGF receptor. PDGF-BB exerts beneficial effects on haemorrhagic shock, which are closely related to targeting CX43 to improve vascular reactivity and haemodynamics. PDGF-BB functions in corporal cavernosum smooth muscle cells (CCSMCs) via binding to PDGFR. |
*本产品仅供科研试验用，不可直接用于人体。
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