| 产品名称 | Human OSM Protein |
|---|---|
| 中文名称 | 重组人肿瘤抑制素M |
| 种属 | Human |
| 表达宿主 | E. coli |
| 纯度 | > 96 % as determined by SDS-PAGE |
| 内毒素 | < 0.1 EU per μg of the protein as determined by the LAL method |
| 生物活性 | Measured by its ability to induce proliferation in TF-1 cells. The ED50 for this effect is 0.4436 ng/mL.The specific activity of recombinant Human OSM is approximately >2.25 x 106 IU/mg. |
| 基因编号 | 5008 |
| 蛋白链接 | https://www.uniprot.org/uniprotkb/P13725/entry |
| 别名 | Oncostatin-M; OSM |
| 蛋白序列 | AAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRR |
| 蛋白标签 | Tag free |
| 预测分子量 | The recombinant Mouse OSM consists of 227 amino acids and predicts a molecular mass of 25.7 kDa |
| 产品形式 | Lyophilized from 20mM Tris, 150mM NaCl, pH 8.0. |
| 使用方式 | Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized protein using the buffer we provided not less than 100 µg/ml, which can then be further diluted to other aqueous solutions |
| 运输方式 | The product is shipped at ambient temperature |
| 储存条件 | Store at -20°C |
| 产品背景 | Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi’s sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi’s sarcoma cells, but inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells. OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF. Human OSM is active on murine cells. Recombinant Human Oncostatin M is a 25.7 kDa protein, containing 227 amino acid residues (full length precursor). |
*本产品仅供科研试验用，不可直接用于人体。
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