| 产品名称 | Human TRAIL Protein |
|---|---|
| 中文名称 | 重组人TNF相关的凋亡诱导配体 |
| 种属 | Human |
| 表达宿主 | E. coli |
| 纯度 | >92 % as determined by SDS-PAGE |
| 内毒素 | < 1.0 EU per µg of the protein as determined by the LAL method |
| 生物活性 | Measured by its ability to induce cytotoxicity in the presence of the metabolic inhibitor actinomycin D.The ED50 for this effect is 26.27 ng/mL |
| 基因编号 | 8743 |
| 蛋白链接 | https://www.uniprot.org/uniprotkb/P50591/entry |
| 别名 | Apo-2 ligand (Apo-2L) TNF-related apoptosis-inducing ligand (Protein TRAIL) |
| 蛋白序列 | MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG |
| 蛋白标签 | Tag free |
| 预测分子量 | The recombinant human TRAIL consists of 168 amino acids and has a predicted molecular mass of 19.5 kDa |
| 产品形式 | Lyophilized from sterile 20 mM Tris, 150 mM NaCl, pH 8.0 |
| 使用方式 | Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human TRAIL protein using the buffer we provided not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. |
| 运输方式 | The product is shipped at ambient temperature |
| 储存条件 | Store at -20°C |
| 产品背景 | The protein encoded by Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3 |
*本产品仅供科研试验用，不可直接用于人体。
本产品已被 1 篇文献引用
1
TMB Signature-Related RCAN2 Promotes Apoptosis by Upregulating EHF/DR5 Pathway in Hepatocellular Carcinoma." Frontiers in Bioscience-Landmark 29.7 (2024): 243.
期刊：Frontiers in Bioscience-Landmark
日期：2024