| 产品名称 | Human NRG1 Beta1 Protein |
|---|---|
| 中文名称 | 重组人神经调节蛋白1-β1 |
| 种属 | Human |
| 表达宿主 | E. coli |
| 纯度 | > 99 % as determined by SDS-PAGE |
| 内毒素 | <1.0 EUper μg of the protein as determined by the LAL method. |
| 生物活性 | Measured by its ability to induce proliferation in MCF-7 cells. The ED50 for this effect is 0.6730 ng/mL. |
| 基因编号 | 3084 |
| 蛋白链接 | https://www.uniprot.org/uniprotkb/Q02297/entry |
| 别名 | NRG1; Neu differentiation factor; Sensory and motor neuron-derived factor; |
| 蛋白序列 | MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV |
| 蛋白标签 | Tag free |
| 预测分子量 | The Recombinant Human NRG1 Beta1 Protein consists of 220 amino acids and predicts a molecular mass of 24.04KDa |
| 产品形式 | Lyophilized from sterile 20 mM Tris with 150 mM NaCl, pH 7.4. |
| 使用方式 | Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Recombinant Human NRG1 Beta1 Protein using the buffer we provided not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| 运输方式 | The product is shipped at ambient temperature |
| 储存条件 | Store at -20°C |
| 产品背景 | Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44 kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis |
*本产品仅供科研试验用，不可直接用于人体。
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