| 产品名称 | Human BMP-7 Protein |
|---|---|
| 中文名称 | 重组人骨形态发生蛋白-7 |
| 种属 | Human |
| 表达宿主 | E. coli |
| 纯度 | > 98 % as determined by SDS-PAGE |
| 内毒素 | <0.1 EU per μg of the protein by the LAL method. |
| 生物活性 | Measure by its ability to induce alkaline phosphatase production by ATDC5 cells. The ED50 for this effect is 5 ng/mL. The specific activity of recombinant Human Noggin is approximately >2.00x 105 IU/mg. As shown in the figure below, the number of positive cells increased as the concentration of BMP7 protein was added, and this effect was measured by the TRAP kit. |
| 基因编号 | 655 |
| 蛋白链接 | https://www.uniprot.org/uniprotkb/P18075/entry |
| 别名 | Osteogenic protein 1 (OP-1) |
| 蛋白序列 | STGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH |
| 蛋白标签 | Tag free |
| 预测分子量 | The recombinant Human BMP-7 Protein consists of 117 amino acids and predicts a molecular mass of 13.2 kDa. |
| 产品形式 | Lyophilized from 20 mM Tris-HCl, 150 mM NaCl, pH 7.4. |
| 使用方式 | Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized protein using the buffer we provided not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. |
| 运输方式 | The product is shipped at ambient temperature. |
| 储存条件 | Store at -20°C |
| 产品背景 | Bone morphogenetic protein 7 (BMP-7) is a multifunctional ligand protein belongs to the TGF-β family. BMP-7 is involved in regulating the proliferation, invasion, and migration of cancer cells, and is associated with various human tumors. BMP-7 binds to ALK2 or ACVR2A/BMPR2 excitation signals, which are regulated and terminated by SMADs. BMP-7 is involved in the BMP-7 Smad1/5/9 signaling pathway and is associated with the epithelial mesenchymal transition (EMT) process. BMP-7 also eliminates vascular inflammation, maintains vascular integrity, weakens vascular calcification, and stimulates in situ phosphorylation deposition. The growth factor domain of human BMP-7 shares 98% aa sequence identity with mouse and rat BMP-7. |
*本产品仅供科研试验用，不可直接用于人体。
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