| 产品名称 | Rat CNTF Protein |
|---|---|
| 中文名称 | 重组大鼠睫状神经营养因子 |
| 种属 | Rat |
| 表达宿主 | E. coli |
| 纯度 | > 97 % as determined by SDS-PAGE |
| 内毒素 | <1 EU per μg of the protein as determined by the LAL method. |
| 生物活性 | Measured in a cell proliferation assay using TF-1. The ED50 for this effect is 0.02748 ng/mL. The specific activity of recombinant Rat CNTF is approximately > 3.64×107 IU/mg. |
| 基因编号 | 25707 |
| 蛋白链接 | https://www.uniprot.org/uniprotkb/P20294/entry |
| 别名 | Rat CNTF |
| 蛋白序列 | MAFAEQTPLTLHRRDLCSRSIWLARKIRSDLTALMESYVKHQGLNKNINLDSVDGVPVASTDRWSEMTEAERLQENLQAYRTFQGMLTKLLEDQRVHFTPTEGDFHQAIHTLMLQVSAFAYQLEELMVLLEQKIPENEADGMPATVGDGGLFEKKLWGLKVLQELSQWTVRSIHDLRVISSHQMGISALESHYGAKDKQM |
| 蛋白标签 | Tag free |
| 预测分子量 | The recombinant Rat CNTF consisting of 200 amino acids and has a calculated molecular mass of 22.9 kDa. It migrates as an approximately 24 kDa band in SDS-PAGE under reducing conditions. |
| 产品形式 | Liquid in from sterile 20 mM Tris 50mM NaCl ,pH 8.0. |
| 使用方式 | Always centrifuge tubes before opening. It is recommended to diluted the protein using the PBS buffer or Protein storage solution to working concentration. |
| 运输方式 | The product is shipped at gel pack with blue ice. |
| 储存条件 | Store at -20°C |
| 产品背景 | Ciliary neurotrophic factor (CNTF) is a member of the cytokine family. It is a polypeptide hormone that has the function of promoting the synthesis of neurotransmitters and the growth of neurites in a specific neuronal population. Its action seems to be limited to the nervous system. Ciliary neurotrophic factor (CNTF) exerts its biological effects by activating a multi-subunit receptor complex consisting of an extracellular CNTF-binding subunit (CNTFα) and two transmembrane signaling proteins (glycoprotein gp130 and LIF receptor). CNTF is thought to be a potent survival factor in neurons and oligodendrocytes and may be associated with reduced tissue destruction during inflammatory episodes. CNTF is also a survival factor for peripheral sensory sympathetic ganglions and ciliary ganglia neurons. CNTF has been reported to have therapeutic potential and to greatly differentiate. |
*本产品仅供科研试验用，不可直接用于人体。
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