| 产品名称 | Mouse IL-1α Protein |
|---|---|
| 中文名称 | 重组小鼠白介素-1α |
| 种属 | Mouse |
| 表达宿主 | E. coli |
| 纯度 | > 98 % as determined by SDS-PAGE |
| 内毒素 | < 0.01 EU per μg of the protein as determined by the LAL method. |
| 生物活性 | Measured by its ability to induce proliferation in CTLL-2 cells ,The ED50 for this effect is 0.001641 ng/mL； Immobilized Mouse IL-1α protein at 1 μg/mL (100 ul/well) can bind mouse IL1R1, The EC50 of mouse IL1R1 is 0.65 μg/mL. The Specific activity of recombinant Mouse IL-1α is approximately > 1.53x106 IU/mg. |
| 基因编号 | 16175 |
| 蛋白链接 | https://www.uniprot.org/uniprotkb/P16598/entry |
| 别名 | Il1a |
| 蛋白序列 | MAKVPDLFEDLKNCYSENEEYSSAIDHLSLNQKSFYDASYGSLHENCTDKFVSLRTSETSKMSTFTFKESRVVVSATSNKGKILKKRRLSFNQPFTEDDLEAIAHDLEETIQPRSAPHSFQNNLRYKLIRIVKQEFIMNDSLNQNIYVDMDRIHLKAASLNDLQLEVKFDMYAYSSGGDDSKYPVTLKVSNTQLFVSAQGEDKPVLLKEIPETPKLITGSETDLIFFWEKINSKNYFTSAAFPELLIATKEQSQVHLARGLPSMIDFQIS |
| 蛋白标签 | Tag free |
| 预测分子量 | The recombinant Mouse IL-1α protein consists of 156 amino acids and has a predicted molecular mass of 18 kDa. |
| 产品形式 | Lyophilized from sterile 20 mM Tris with 150 mM NaCl, pH 7.4. |
| 使用方式 | Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Mouse IL-1α protein using the buffer we provided not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| 运输方式 | The product is shipped at ambient temperature. |
| 储存条件 | Store at -20℃ |
| 产品背景 | IL-1α is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. IL-1α is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. It is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1α stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. |
*本产品仅供科研试验用，不可直接用于人体。
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