Human FGF-8b Protein, His tag (Animal-Free)
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| 产品名称 | Human FGF-8b Protein, His tag (Animal-Free) |
|---|---|
| 中文名称 | 重组人成纤维细胞生长因子8b，His-标签（无动物源）（FGF-8b） |
| 种属 | Human |
| 表达宿主 | E. coli |
| 纯度 | > 95 % as determined by SDS-PAGE |
| 内毒素 | <1 EU per μg of the protein by the LAL method. |
| 生物活性 | Measured in a cell proliferation assay using Balb/c 3T3 mouse embryonic fibroblasts. The ED50 for this effect is typically 17.58 ng/mL. The specific activity of recombinant FGF8b is approximately >5.69 x 104 IU/mg. |
| 基因编号 | 2253 |
| 蛋白链接 | https://www.uniprot.org/uniprotkb/P55075/entry |
| 别名 | AIGF, FGF-8, HBGF-8, HH6, KAL6 |
| 蛋白序列 | QEGPGRGPALGRELASLFRAGREPQGVSQQHVREQSLVTDQLSRRLIRTYQLYSRTSGKHVQVLANKRINAMAEDGDPFAKLIVETDTFGSRVRVRGAETGLYICMNKKGKLIAKSNGKGKDCVFTEIVLENNYTALQNAKYEGWYMAFTRKGRPRKGSKTRQHQREVHFMKRLPRGHHTTEQSLRFEFLNYPPFTRSLRGSQRTWAPEPR |
| 蛋白标签 | C-His |
| 预测分子量 | The recombinant human FGF8b consists 194 amino acids and predicts a molecular mass of 22.5 kDa. |
| 产品形式 | Lyophilized from sterile 20 mM Tris, 150 mM NaCl, pH 7.4. |
| 使用方式 | Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Mouse IFN-γ protein in sterile ddH2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| 运输方式 | The product is shipped at ambient temperature. |
| 储存条件 | Store at -20°C |
| 产品背景 | In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling factor, and its precise regulation is essential for embryo patterning. |
*本产品仅供科研试验用，不可直接用于人体。
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